diff --git a/src/sections/Cultivos.tsx b/src/sections/Cultivos.tsx
index 4e4a14e..69a7452 100644
--- a/src/sections/Cultivos.tsx
+++ b/src/sections/Cultivos.tsx
@@ -172,41 +172,51 @@ export function Cultivos({
                       Protocolo: {cultivo.protocolo}
                     </p>
                   )}
-                  {cultivo.observaciones && (
-                    <p className="text-sm text-gray-600 dark:text-gray-300 bg-gray-50 dark:bg-gray-800 p-2 rounded">
-                      {cultivo.observaciones}
+
+                  {cultivo.estado === 'NAF/Pendiente' && cultivo.observaciones && (
+                    <p className="text-sm text-gray-600 dark:text-gray-300 bg-gray-50 dark:bg-gray-800 p-2.5 rounded border border-gray-200 dark:border-gray-700">
+                      <span className="font-semibold">Observaciones:</span> {cultivo.observaciones}
                     </p>
                   )}
 
-                  {cultivo.estado === 'Parcial' && cultivo.germen && (
-                    <div className="bg-orange-50 p-3 rounded-lg border border-orange-200">
-                      <p className="text-sm font-medium text-orange-800 flex items-center gap-2">
-                        <AlertCircle className="h-4 w-4" />
-                        PARCIAL - Germen: {cultivo.germen}
-                      </p>
+                  {cultivo.estado === 'Parcial' && (
+                    <div className="bg-orange-50 dark:bg-orange-950/60 p-3 rounded-lg border border-orange-200 dark:border-orange-800/50 space-y-2">
+                      {cultivo.germen && (
+                        <p className="text-sm font-medium text-orange-800 dark:text-orange-300 flex items-center gap-2">
+                          <AlertCircle className="h-4 w-4" />
+                          PARCIAL - Germen: {cultivo.germen}
+                        </p>
+                      )}
                       {(cultivo.sensible || cultivo.resistente) && (
-                        <div className="mt-2 space-y-1">
+                        <div className="space-y-1">
                           {cultivo.sensible && (
-                            <p className="text-xs text-orange-700">Sensible: {cultivo.sensible}</p>
+                            <p className="text-xs text-orange-700 dark:text-orange-300">Sensible: {cultivo.sensible}</p>
                           )}
                           {cultivo.resistente && (
-                            <p className="text-xs text-orange-700">Resistente: {cultivo.resistente}</p>
+                            <p className="text-xs text-orange-700 dark:text-orange-300">Resistente: {cultivo.resistente}</p>
                           )}
                         </div>
                       )}
+                      {cultivo.observaciones && (
+                        <p className="text-xs text-orange-800 dark:text-orange-200 border-t border-orange-200 dark:border-orange-800/60 pt-2 mt-1">
+                          <span className="font-semibold">Observaciones:</span> {cultivo.observaciones}
+                        </p>
+                      )}
                     </div>
                   )}
 
-                  {cultivo.estado === 'Positivo' && cultivo.germen && (
-                    <div className="flex flex-col gap-2.5 mt-2">
+                  {cultivo.estado === 'Positivo' && (
+                    <div className="flex flex-col gap-2 mt-2">
                       <div className="flex flex-wrap gap-2">
-                        <Badge 
-                          variant="outline" 
-                          className="border-red-600 border bg-red-50 text-red-800 dark:bg-red-950/60 dark:text-red-300 dark:border-red-500 rounded px-2.5 py-1 font-medium text-sm inline-flex items-center gap-1.5"
-                        >
-                          <AlertCircle className="h-4 w-4 text-red-600 shrink-0" />
-                          <span>Germen: {cultivo.germen} {cultivo.fechaResultado ? `(Definitivo: ${cultivo.fechaResultado})` : ''}</span>
-                        </Badge>
+                        {cultivo.germen && (
+                          <Badge 
+                            variant="outline" 
+                            className="border-red-600 border bg-red-50 text-red-800 dark:bg-red-950/60 dark:text-red-300 dark:border-red-500 rounded px-2.5 py-1 font-medium text-sm inline-flex items-center gap-1.5"
+                          >
+                            <AlertCircle className="h-4 w-4 text-red-600 shrink-0" />
+                            <span>Germen: {cultivo.germen} {cultivo.fechaResultado ? `(Definitivo: ${cultivo.fechaResultado})` : ''}</span>
+                          </Badge>
+                        )}
 
                         {cultivo.sensible && (
                           <Badge 
@@ -226,15 +236,26 @@ export function Cultivos({
                           </Badge>
                         )}
                       </div>
+
+                      {cultivo.observaciones && (
+                        <div className="bg-red-50/60 dark:bg-red-950/40 p-2.5 rounded-md border border-red-200/80 dark:border-red-900/50 text-xs text-red-900 dark:text-red-200">
+                          <span className="font-semibold">Observaciones:</span> {cultivo.observaciones}
+                        </div>
+                      )}
                     </div>
                   )}
 
                   {cultivo.estado === 'Negativo' && (
-                    <div className="bg-green-50 p-3 rounded-lg border border-green-200">
-                      <p className="text-sm font-medium text-green-800 flex items-center gap-2">
+                    <div className="bg-green-50 dark:bg-green-900/60 p-3 rounded-lg border border-green-200 dark:border-green-700 mt-2 space-y-2">
+                      <p className="text-sm font-medium text-green-800 dark:text-green-200 flex items-center gap-2">
                         <CheckCircle2 className="h-4 w-4" />
                         Cultivo Negativo
                       </p>
+                      {cultivo.observaciones && (
+                        <p className="text-xs text-green-800 dark:text-green-200 border-t border-green-200 dark:border-green-700/80 pt-2 mt-1">
+                          <span className="font-semibold">Observaciones:</span> {cultivo.observaciones}
+                        </p>
+                      )}
                     </div>
                   )}
                 </div>
diff --git a/src/sections/HistoriaClinica.tsx b/src/sections/HistoriaClinica.tsx
index fba2651..3dc1205 100644
--- a/src/sections/HistoriaClinica.tsx
+++ b/src/sections/HistoriaClinica.tsx
@@ -1,4 +1,4 @@
-import { useState } from 'react';
+import { useState, useEffect } from 'react';
 import { createPortal } from 'react-dom';
 import { toast } from 'sonner';
 import { User } from 'lucide-react';
@@ -55,9 +55,8 @@ import { Label } from '@/components/ui/label';
 import { Textarea } from '@/components/ui/textarea';
 import { Dialog, DialogContent, DialogHeader, DialogTitle } from '@/components/ui/dialog';
 import { Select, SelectContent, SelectItem, SelectTrigger, SelectValue, SelectGroup, SelectLabel } from '@/components/ui/select';
-import { Tabs, TabsContent, TabsList, TabsTrigger } from '@/components/ui/tabs';
+import { Tabs, TabsContent } from '@/components/ui/tabs';
 import { Table, TableBody, TableCell, TableHead, TableHeader, TableRow } from '@/components/ui/table';
-import { ScrollArea, ScrollBar } from "@/components/ui/scroll-area"
 import { DropdownMenu, DropdownMenuContent, DropdownMenuItem, DropdownMenuTrigger } from '@/components/ui/dropdown-menu';
 import { LineChart, Line, XAxis, YAxis, CartesianGrid, Tooltip, ResponsiveContainer } from 'recharts';
 import type { Laboratorio, Glucemia, AcidoBase, Cultivo, Paciente, ResultadoLaboratorio, Internacion, Evolucion, Cama, EstudioComplementario, Interconsulta, ATB, Indicacion, MovimientoIndicacion, Pendiente, OtroLaboratorio } from '@/types';
@@ -203,6 +202,69 @@ function wrapText(text: string, font: { widthOfTextAtSize: (text: string, size:
 
 
 
+function SeccionNotasPaciente({ paciente, canEdit }: { paciente: Paciente; canEdit?: boolean }) {
+  const { actualizarPaciente } = useHospitalStore();
+  const [textoNotas, setTextoNotas] = useState(paciente.notas || '');
+  const [isSaving, setIsSaving] = useState(false);
+  const [guardado, setGuardado] = useState(true);
+
+  useEffect(() => {
+    setTextoNotas(paciente.notas || '');
+    setGuardado(true);
+  }, [paciente.id, paciente.notas]);
+
+  const handleChange = (e: React.ChangeEvent<HTMLTextAreaElement>) => {
+    setTextoNotas(e.target.value);
+    setGuardado(false);
+  };
+
+  const handleGuardar = async () => {
+    try {
+      setIsSaving(true);
+      await actualizarPaciente(paciente.id, { notas: textoNotas });
+      toast.success('Notas del paciente guardadas correctamente');
+      setGuardado(true);
+    } catch (err) {
+      console.error('Error al guardar notas:', err);
+      toast.error('Error al guardar las notas del paciente');
+    } finally {
+      setIsSaving(false);
+    }
+  };
+
+  return (
+    <div className="border-t pt-3 space-y-3">
+      <Textarea
+        className="w-full p-3 text-sm min-h-[120px] bg-background text-foreground focus:ring-2 focus:ring-primary focus:outline-none disabled:opacity-60 disabled:cursor-not-allowed resize-y"
+        placeholder="Escriba aquí las notas generales del paciente..."
+        value={textoNotas}
+        onChange={handleChange}
+        disabled={!canEdit || isSaving}
+      />
+      <div className="flex items-center justify-between gap-2">
+        <div>
+          {!guardado && (
+            <span className="text-xs text-amber-600 dark:text-amber-400 font-medium">
+              Cambios sin guardar
+            </span>
+          )}
+        </div>
+        {canEdit && (
+          <Button
+            size="sm"
+            onClick={handleGuardar}
+            disabled={isSaving || guardado}
+            className="flex items-center gap-1.5"
+          >
+            <Save className="h-4 w-4" />
+            {isSaving ? 'Guardando...' : 'Guardar Notas'}
+          </Button>
+        )}
+      </div>
+    </div>
+  );
+}
+
 export function HistoriaClinica({
   internacion,
   paciente,
@@ -389,11 +451,11 @@ export function HistoriaClinica({
                 </>
               )}
 
-              <Accordion type="single" collapsible>
+              <Accordion type="multiple" className="w-full space-y-1">
                 <AccordionItem value="item-1">
                   <AccordionTrigger>Detalle Episodio Actual</AccordionTrigger>
-                  <AccordionContent className="p4">
-                    <div className="border-t space-y-4">
+                  <AccordionContent>
+                    <div className="border-t space-y-4 pt-3">
 
 
                       <div>
@@ -527,6 +589,13 @@ export function HistoriaClinica({
                     </div>
                   </AccordionContent>
                 </AccordionItem>
+
+                <AccordionItem value="notas">
+                  <AccordionTrigger>Notas</AccordionTrigger>
+                  <AccordionContent>
+                    <SeccionNotasPaciente paciente={paciente} canEdit={canEdit} />
+                  </AccordionContent>
+                </AccordionItem>
               </Accordion>
 
             </div>
@@ -1315,7 +1384,7 @@ function SeccionLaboratorios({ lab, otrosLaboratorios = [], patientId, internaci
           }
 
           // Clean parenthesized reference values/ranges if present (e.g. "(1.6 - 2.6 mg/dL)")
-          let cleanSubLinea = subLinea.replace(/\([^)]*?(?:-|–|—|:|[0-9]\s*[-–—]\s*[0-9]|ref|vr|val|norm|min|max)[^)]*?\)/gi, ' ');
+          const cleanSubLinea = subLinea.replace(/\([^)]*?(?:-|–|—|:|[0-9]\s*[-–—]\s*[0-9]|ref|vr|val|norm|min|max)[^)]*?\)/gi, ' ');
 
           let match = cleanSubLinea.match(/(\d+(?:[.,]\d+)?)/);
           if (!match) {
@@ -1763,10 +1832,10 @@ function SeccionLaboratorios({ lab, otrosLaboratorios = [], patientId, internaci
                         <Badge variant="secondary" className="text-[10px] px-1.5 py-0.5">{item.source === 'lab' ? 'Obs. de Lab' : 'Otros'}</Badge>
                         {canEdit && (
                           <div className="flex items-center gap-1">
-                            <Button size="icon" variant="ghost" className="h-6 w-6 text-gray-600 dark:text-gray-300 hover:bg-gray-200 dark:hover:bg-gray-700" onClick={() => handleStartEditOtros(item as any)} title="Editar">
+                            <Button size="icon" variant="ghost" className="h-6 w-6 text-gray-600 dark:text-gray-300 hover:bg-gray-200 dark:hover:bg-gray-700" onClick={() => handleStartEditOtros(item as OtroLaboratorio)} title="Editar">
                               <Pencil className="h-3.5 w-3.5" />
                             </Button>
-                            <Button size="icon" variant="ghost" className="h-6 w-6 text-red-600 hover:text-red-700 hover:bg-red-50 dark:hover:bg-red-950/40" onClick={() => handleDeleteOtros(item as any)} title="Eliminar">
+                            <Button size="icon" variant="ghost" className="h-6 w-6 text-red-600 hover:text-red-700 hover:bg-red-50 dark:hover:bg-red-950/40" onClick={() => handleDeleteOtros(item as OtroLaboratorio)} title="Eliminar">
                               <Trash2 className="h-3.5 w-3.5" />
                             </Button>
                           </div>
@@ -2672,12 +2741,14 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
     setGermen('');
     setSensible('');
     setResistente('');
+    setObservaciones('');
     setSelected(null);
   };
 
   const openParcial = (c: Cultivo) => {
     setSelected(c);
     setProtocolo(c.protocolo || '');
+    setObservaciones(c.observaciones || '');
     setGermen(c.germen || '');
     setSensible(c.sensible || '');
     setResistente(c.resistente || '');
@@ -2687,6 +2758,7 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
   const openDefinitivo = (c: Cultivo) => {
     setSelected(c);
     setProtocolo(c.protocolo || '');
+    setObservaciones(c.observaciones || '');
     setFechaResultado(c.fechaResultado || getLocalToday());
     setEstadoResultado(c.estado === 'Parcial' ? 'Positivo' : c.estado);
     setGermen(c.germen || '');
@@ -2725,6 +2797,7 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
       germen, 
       sensible, 
       resistente, 
+      observaciones: observaciones || undefined,
       fechaResultado: selected.fechaResultado || getLocalToday() 
     });
     setResDialog(false);
@@ -2733,7 +2806,15 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
 
   const handleDefinitivo = () => {
     if (!selected) return;
-    update(selected.id, { protocolo, fechaResultado, estado: estadoResultado, germen, sensible, resistente });
+    update(selected.id, { 
+      protocolo, 
+      fechaResultado, 
+      estado: estadoResultado, 
+      germen, 
+      sensible, 
+      resistente,
+      observaciones: observaciones || undefined
+    });
     setEditDialog(false);
     resetRes();
   };
@@ -2801,6 +2882,7 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
             <div><Label>Germen *</Label><Input value={germen} onChange={e => setGermen(e.target.value)} placeholder="Ej: Staphylococcos aureus" /></div>
             <div><Label>Sensible a:</Label><Input value={sensible} onChange={e => setSensible(e.target.value)} placeholder="Ej: Amikacina, Vancomicina" /></div>
             <div><Label>Resistente a:</Label><Input value={resistente} onChange={e => setResistente(e.target.value)} placeholder="Ej: Oxacilina" /></div>
+            <div><Label>Observaciones</Label><textarea className="w-full p-2 border rounded-md text-sm min-h-[60px]" value={observaciones} onChange={e => setObservaciones(e.target.value)} placeholder="Observaciones de la muestra o resultado parcial..." /></div>
           </div>
           <div className="flex justify-end gap-2 mt-4"><Button variant="outline" onClick={() => { resetRes(); setResDialog(false); }}><X className="h-4 w-4 mr-2" />Cancelar</Button><Button variant="outline" onClick={handleParcial} disabled={!germen}><Save className="h-4 w-4 mr-2" />Guardar Parcial</Button></div>
         </DialogContent>
@@ -2830,6 +2912,7 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
                 <div><Label>Resistente a:</Label><Input value={resistente} onChange={e => setResistente(e.target.value)} placeholder="Ej: Ampicilina, Cefazolina" /></div>
               </>
             )}
+            <div><Label>Observaciones</Label><textarea className="w-full p-2 border rounded-md text-sm min-h-[60px]" value={observaciones} onChange={e => setObservaciones(e.target.value)} placeholder="Observaciones de la muestra o resultado definitivo..." /></div>
           </div>
           <div className="flex justify-end gap-2 mt-4"><Button variant="outline" onClick={() => { resetRes(); setEditDialog(false); }}><X className="h-4 w-4 mr-2" />Cancelar</Button><Button variant="outline" onClick={handleDefinitivo} disabled={estadoResultado === 'Positivo' && !germen}><Save className="h-4 w-4 mr-2" />Guardar Definitivo</Button></div>
         </DialogContent>
@@ -2877,29 +2960,44 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
                       {c.estado === 'Parcial' ? 'Fecha Resultado Parcial' : 'Fecha Definitivo'}: {formatDateDDMMYYYY(c.fechaResultado)}
                     </p>
                   )}
-                  {c.observaciones && <p className="text-sm text-gray-600 dark:text-gray-300 bg-gray-50 dark:bg-gray-800 p-2 rounded">{c.observaciones}</p>}
-                  {c.estado === 'Parcial' && c.germen && (
-                    <div className="bg-orange-50 dark:bg-orange-950/60 p-3 rounded-lg border border-orange-200 dark:border-orange-800/50">
-                      <p className="text-sm font-medium text-orange-800 dark:text-orange-300 flex items-center gap-2"><AlertCircle className="h-4 w-4" />PARCIAL - Germen: {c.germen}</p>
+                  {c.estado === 'NAF/Pendiente' && c.observaciones && (
+                    <p className="text-sm text-gray-600 dark:text-gray-300 bg-gray-50 dark:bg-gray-800 p-2.5 rounded border border-gray-200 dark:border-gray-700">
+                      <span className="font-semibold">Observaciones:</span> {c.observaciones}
+                    </p>
+                  )}
+                  {c.estado === 'Parcial' && (
+                    <div className="bg-orange-50 dark:bg-orange-950/60 p-3 rounded-lg border border-orange-200 dark:border-orange-800/50 space-y-2">
+                      {c.germen && (
+                        <p className="text-sm font-medium text-orange-800 dark:text-orange-300 flex items-center gap-2">
+                          <AlertCircle className="h-4 w-4" />PARCIAL - Germen: {c.germen}
+                        </p>
+                      )}
                       {(c.sensible || c.resistente) && (
-                        <div className="mt-2 space-y-1">
+                        <div className="space-y-1">
                           {c.sensible && <p className="text-xs text-orange-700 dark:text-orange-300">Sensible: {c.sensible}</p>}
                           {c.resistente && <p className="text-xs text-orange-700 dark:text-orange-300">Resistente: {c.resistente}</p>}
                         </div>
                       )}
+                      {c.observaciones && (
+                        <p className="text-xs text-orange-800 dark:text-orange-200 border-t border-orange-200 dark:border-orange-800/60 pt-2 mt-1">
+                          <span className="font-semibold">Observaciones:</span> {c.observaciones}
+                        </p>
+                      )}
                     </div>
                   )}
-                  {c.estado === 'Positivo' && c.germen && (
+                  {c.estado === 'Positivo' && (
                     <div className="flex flex-col gap-2 mt-2">
-                      <div>
-                        <Badge 
-                          variant="outline" 
-                          className="border-solid border-2 border-red-600 bg-red-50 text-red-800 dark:bg-red-950/60 dark:text-red-300 dark:border-red-500 rounded px-2.5 py-1 font-semibold text-sm inline-flex items-center gap-1.5"
-                        >
-                          <AlertCircle className="h-4 w-4 text-red-600 shrink-0" />
-                          <span>Germen: {c.germen}</span>
-                        </Badge>
-                      </div>
+                      {c.germen && (
+                        <div>
+                          <Badge 
+                            variant="outline" 
+                            className="border-solid border-2 border-red-600 bg-red-50 text-red-800 dark:bg-red-950/60 dark:text-red-300 dark:border-red-500 rounded px-2.5 py-1 font-semibold text-sm inline-flex items-center gap-1.5"
+                          >
+                            <AlertCircle className="h-4 w-4 text-red-600 shrink-0" />
+                            <span>Germen: {c.germen}</span>
+                          </Badge>
+                        </div>
+                      )}
 
                       {(c.sensible || c.resistente) && (
                         <div className="flex flex-wrap gap-2">
@@ -2922,11 +3020,22 @@ function SeccionCultivos({ cults, patient, internacionId, add, update, del, canE
                           )}
                         </div>
                       )}
+
+                      {c.observaciones && (
+                        <div className="bg-red-50/60 dark:bg-red-950/40 p-2.5 rounded-md border border-red-200/80 dark:border-red-900/50 text-xs text-red-900 dark:text-red-200">
+                          <span className="font-semibold">Observaciones:</span> {c.observaciones}
+                        </div>
+                      )}
                     </div>
                   )}
                   {c.estado === 'Negativo' && (
-                    <div className="bg-green-50 dark:bg-green-900 p-3 rounded-lg border border-green-200 dark:border-green-700 mt-2">
-                      <p className="text-sm font-medium text-green-800 flex items-center gap-2"><CheckCircle2 className="h-4 w-4" />Sin crecimiento de microorganismos</p>
+                    <div className="bg-green-50 dark:bg-green-900/60 p-3 rounded-lg border border-green-200 dark:border-green-700 mt-2 space-y-2">
+                      <p className="text-sm font-medium text-green-800 dark:text-green-200 flex items-center gap-2"><CheckCircle2 className="h-4 w-4" />Sin crecimiento de microorganismos</p>
+                      {c.observaciones && (
+                        <p className="text-xs text-green-800 dark:text-green-200 border-t border-green-200 dark:border-green-700/80 pt-2 mt-1">
+                          <span className="font-semibold">Observaciones:</span> {c.observaciones}
+                        </p>
+                      )}
                     </div>
                   )}
                 </div>
diff --git a/src/types/index.ts b/src/types/index.ts
index 78b69e4..80b903a 100644
--- a/src/types/index.ts
+++ b/src/types/index.ts
@@ -18,6 +18,7 @@ export interface Paciente {
   nacionalidad?: string;
   medicacionHabitual?: string;
   historiaClinica?: string;
+  notas?: string;
 }